Clinical Summary
>Biochemistry
Physician - Clinical - Basic Science - Biochemistry
Clinical - Basic Science:
Biochemistry
Percutaneous Plasma Decompression
Alters Cytokine Expression in Injured
Porcine Intervertebral Discs.
C. O'Neill, J. Liu, E. Leibenberg, S. Hu, V.
Deviren, B. Tay, C. Chin and J. Lotz.
The Spine Journal (2004) 4: 115-118
Key Point
Significant biochemical changes in the
degenerative disc.
Analysis
• Adult porcine model used to evaluate
Nucleoplasty efficacy
• Discs treated with Nucleoplasty
showed incease in IL-8 and decrease
in IL-1
• No difference in morphological and
biomechanical parameters between
treated & non treated discs
• Nucleoplasty leads to a decrease
in IL-1 and increase of IL-8
Outcome
• Alteration in cytokine expression is
consistent with a mechanism of pain
relief
• Nucleoplasty may be capable of initiating
a repair response in the disc